A new study reveals that a personalized, monitored approach to vitamin D3 supplementation after a heart attack can dramatically cut the risk of a second heart attack.
A new study reports that a personalized method of vitamin D3 supplementation can greatly lower the chances of a second heart attack in patients who have already experienced one.
In a large randomized clinical trial, researchers discovered that using a “target to treat” strategy—where patients’ vitamin D levels were routinely measured and supplement doses were adjusted to reach an optimal range—cut the risk of another heart attack by 50 percent.
The findings were recently unveiled at the 2025 American Heart Association Scientific Sessions in New Orleans.
The results are promising, said Heidi May, PhD, cardiovascular epidemiologist at Intermountain Health and principal investigator of the study
“We observed no adverse outcomes when giving patients higher doses of vitamin D3 supplementation, and to significantly reduce the risk of another heart attack, which are exciting results,” said Dr. May. “We’re excited with these results but know we have further work to do to validate these findings.”
This research carries broad significance, as an estimated one-half to two-thirds of the global population has insufficient levels of vitamin D.
